Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1 dose
300 mg once daily
Drug 1 effect
AUC increase 40%-98%, Cmin increase 55-80% when TDF coadministered with rilpivirine and efavirenz or various PIs, INSTIs, and NNRTIs
Drug 2
Drug 2 dose
90 / 400 mg once daily
Drug 2 effect
Not studied
Clinical Effects
Increased risk of TDF adverse effects (e.g. renal function decline)
Management
If coadministering, monitor for TDF adverse effects. Avoid use if CrCl >60 ml / min.
Import ID
753
