Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1 dose
300 mg once daily
Drug 1 effect
Cmax increase 24%, AUC increase 22%, Cmin increase 37%
Drug 2
Drug 2 dose
300 mg BID with ritonavir 100 mg BID
Drug 2 effect
Cmax increase 16%, AUC increase 21%, Cmin increase 24%
Clinical Effects
Increased risk of TDF and / or darunavir adverse effects
Management
If coadministering, monitor for TDF adverse effects (e.g. renal function decline)
Import ID
752
