Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1 dose
300 mg once daily
Drug 1 effect
Cmax increased 36%; AUC increased 35%; Cmin increased 45%
Drug 2
Drug 2 dose
400 / 100mg once daily
Drug 2 effect
Not studied
Clinical Effects
Potentially increased risk of TDF adverse effects (e.g. renal function decline)
Management
If coadministering, monitor for TDF adverse effects
Import ID
750
