Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid altered levels of atazanavir and TDF
Drug 1 effect
Not studied (may increase TDF levels)
Drug 2
Drug 2 effect
Not studied (may decrease atazanavir levels)
Clinical Effects
Potentially increased risk of TDF adverse effects and decreased efficacy of atazanavir
Management
If coadministering atazanavir, cobicistat, tenofovir, and an H2 receptor antagonist in a treatment-experienced patient, increase atazanavir dose to 400 mg
Import ID
729
