Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid altered levels of atazanavir and TDF
Drug 1 dose
300 mg once daily, separated 12 hours away from atazanavir / ritonavir
Drug 1 effect
Cmax increase 34%, AUC increase 37%, Cmin increase 29%
Drug 2
Drug 2 dose
300 mg once daily with 100 mg ritonavir daily
Drug 2 effect
Cmax decrease 28%, AUC decrease 25%, Cmin decrease 23%
Clinical Effects
Increased tenofovir effects, decreased atazanavir effects
Management
Do not coadminister with unboosted atazanavir (400 mg). Administer 300 mg atazanavir with 100 mg ritonavir when used as part of a tenofovir containing regimen. If coadministering atazanavir, ritonavir, tenofovir, and an H2 receptor antagonist in a treatment-experienced patient, increase atazanavir dose to 400 mg (plus 100 mg ritonavir).
Import ID
728
