Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid altered levels of atazanavir and TDF
Drug 1 dose
300 mg once daily with a light meal
Drug 1 effect
Cmax increase 14%, AUC increase 24%, Cmin increase 22%
Drug 2
Drug 2 dose
400 mg once daily with a light meal
Drug 2 effect
Cmax decrease 21%, AUC decrease 25%, Cmin decrease 40%
Clinical Effects
Increased tenofovir effects, decreased atazanavir effects
Management
Do not coadminister with unboosted atazanavir (400 mg). Administer 300 mg atazanavir with 100 mg ritonavir when used as part of a tenofovir containing regimen. If coadministering atazanavir, ritonavir, tenofovir, and an H2 receptor antagonist in a treatment-experienced patient, increase atazanavir dose to 400 mg (plus 100 mg ritonavir).
Import ID
727
