Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid altered levels of atazanavir and TDF
Drug 1 dose
300 mg once daily
Drug 1 effect
Cmax increase 39%, AUC increase 55%, Cmin increase 70%
Drug 2
Drug 2 dose
400 mg once daily with 100 mg ritonavir daily
Drug 2 effect
Cmax increase 31%, AUC increase 38%, Cmin increase 33%
Clinical Effects
Increased atazanavir and tenofovir effects
Management
Do not coadminister with unboosted atazanavir (400 mg). Administer 300 mg atazanavir with 100 mg ritonavir when used as part of a tenofovir containing regimen. If coadministering atazanavir, ritonavir, tenofovir, and an H2 receptor antagonist in a treatment-experienced patient, increase atazanavir dose to 400 mg (plus 100 mg ritonavir).
Import ID
726
