Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
25 mg once daily
Drug 1 effect
Cmax increased 3 - 17%, AUC increased 27-32%
Drug 2
Drug 2 dose
90 / 400 mg once daily
Drug 2 effect
Ledipasvir: Cmax increased 1%, AUC increased 2%, Cmin increased 2%; sofosbuvir: Cmax decreased 4%, AUC increased 5%; sofosbuvir metabolite: Cmax 8%, AUC increased 8%, Cmin increased 10%
Import ID
708
