Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of methadone
Drug 1
Drug 1 dose
600 mg BID
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
40 mg once daily; 90 mg once daily
Drug 2 effect
Methadone clearance increased 22%
Clinical Effects
Potential for decreased methadone effects (e.g., withdrawal)
Management
If coadministering monitor for signs and symptoms of methadone withdrawal. Some patients may require an increased methadone dose
Alternative Agents
Buprenorphine and naloxone
Import ID
666
