Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits when using this combination
Drug 1
Drug 1 dose
200 mg daily x 14 days; 200 mg BID x 14 days
Drug 2
Drug 2 dose
500 mg BID
Drug 2 effect
Clarithromycin AUC decreased 31%; Cmax decreased 23%; Cmin decreased 56%; 14-hydroxy clarithromycin AUC increased 42%, Cmax increased 47%
Clinical Effects
Decreased clarithromycin effects but increased metabolite concentrations
Management
Consider using alternative agents such as Azithromycin
Import ID
641
