Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of ethinyl estradiol and progesterone
Drug 1
Drug 2 dose
Ethinyl estradiol 0.035 mg / Norethindrone 1 mg daily x 30 days
Drug 2 effect
Ethinyl estradiol: AUC decreased 23%; half-life: decreased 44%; Norethindrone: AUC decreased 18%; half-life: decreased 15%
Clinical Effects
Possible contraceptive failure
Management
Use alternative contraceptive method
Import ID
616
