Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of ethinyl estradiol and progesterone
Drug 1
Drug 2 dose
Ethinyl estradiol 0.035 mg / Norethindrone 1 mg x 1 dose
Drug 2 effect
Ethinyl estradiol AUC decreased 19%; Cmax no significant change. Norethindrone AUC decreased 18%
Clinical Effects
Possible contraceptive failure
Management
Use alternative contraceptive method
Alternative Agents
Barrier devices; Condoms
Import ID
615
