Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of atazanavir
Drug 1
Drug 1 dose
200 mg BID days 1-23
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
300 mg atazanavir daily with 100 mg ritonavir daily
Drug 2 effect
Atazanavir AUC decreased 42%; Cmax decreased 28%; Cmin decreased 72%
Clinical Effects
Decreased atazanavir effects
Management
Use alternative agents
Import ID
613
