Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
200 mg daily x 14 days; 200 mg BID x 14 days
Drug 1 effect
No significant change in nevirapine Cmin
Drug 2
Drug 2 dose
150 or 300 mg daily
Drug 2 effect
AUC increased 17%, Cmax increased 28% and 25-O-desacetyl-rifabutin AUC increased 24%
Clinical Effects
Decreased antiviral efficacy
Import ID
595
