Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of methadone
Drug 1
Drug 1 dose
200 mg daily x 14 days; 200 mg BID ³7 days
Drug 2
Drug 2 dose
stable dose: racemic methadone 35-220 mg daily; (R)-methadone 45-115 mg daily
Drug 2 effect
racemic methadone AUC decreased 37%; (R)-methadone AUC decreased 44%
Clinical Effects
Decreased methadone effects (eg, withdrawal)
Management
If coadministering monitor for signs and symptoms of methadone withdrawal. Some patients may require an increased methadone dose
Import ID
583
