Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of methadone
Drug 1
Drug 1 dose
200 mg daily x 14 days; 200 mg BID ³7 days
Drug 1 effect
Nevirapine AUC increased 26%; Cmax increased 21%; Cmin increased 35%
Drug 2
Drug 2 dose
Stable methadone maintenance
Drug 2 effect
Methadone AUC decreased 46%
Clinical Effects
Decreased methadone effects (eg, methadone withdrawal; interaction observed one week into therapy
Management
If coadministering monitor for signs and symptoms of methadone withdrawal. Some patients may require an increased methadone dose
Import ID
582
