Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of methadone
Drug 1
Drug 1 dose
200 mg daily x 14 days; 200 mg BID ³7 days
Drug 1 effect
Nevirapine AUC increased 25%; Cmax increased 17%; Cmin increased 32%
Drug 2
Drug 2 dose
Stable methadone dose
Drug 2 effect
Methadone AUC decreased 51%; Cmax decreased 36%
Clinical Effects
Decreased methadone effects (eg, methadone withdrawal)
Management
If coadministering monitor for signs and symptoms of methadone withdrawal. Some patients may require an increased methadone dose
Import ID
581
