Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of methadone
Drug 1
Drug 1 dose
200 mg daily x 14 days; 200 mg BID ³7 days
Drug 1 effect
Nevirapine AUC decreased 46%; Cmax decreased 42%
Drug 2
Drug 2 dose
stable dose
Drug 2 effect
Not reported
Clinical Effects
Decreased methadone effects
Management
If coadministering monitor for signs and symptoms of methadone withdrawal. Some patients may require an increased methadone dose
Import ID
580
