Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of indinavir
Drug 1
Drug 1 dose
200 mg daily x 14 days; 200 mg BID x 14 days
Drug 2
Drug 2 dose
800 mg Q8H
Drug 2 effect
Indinavir AUC decreased 31%; Cmax decreased 15%, Cmin decreased 44%
Clinical Effects
Decreased indinavir effects
Management
Increase indinavir to 1000 mg Q8H
Import ID
579
