Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: risks likely to outweigh benefits
Drug 1
Drug 1 effect
Etravirine AUC increased 42%; Cmax increased 46%; Cmin increased 46%
Drug 2
Drug 2 dose
500 mg BID
Drug 2 effect
Clarithromycin AUC decreased 37%; Cmax decreased 34%; Cmin decreased 53%; 14-hydroxyclarithromycin AUC increased 21%; Cmax increased 33%
Clinical Effects
Increased etravirine effects; decreased clarithromycin effects
Management
Use alternative macrolide (consider use of azithromycin) for MAC
Alternative Agents
Azithromycin
Import ID
561
