Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
200 mg BID with lopinavir / ritonavir 400 / 100 mg BID
Drug 2
Drug 2 dose
50 mg daily
Drug 2 effect
Dolutegravir AUC increased 11%; Cmin increased 28%
Management
Do not coadminister etravirine with dolutegravir unless atazanavir / ritonavir, darunavir / ritonavir, or lopinavir / ritonavir are also part of the regimen. When using this combo and there is known or clinically suspected INSTI resistance, increase dolutegravir dosage to 50 mg BID.
Import ID
537
