Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
200 mg BID with darunavir / ritonavir 600 / 100 mg BID
Drug 2
Drug 2 dose
50 mg daily
Drug 2 effect
Dolutegravir AUC decreased 25%; Cmin decreased 37%
Clinical Effects
Potentially reduced dolutegravir effectiveness
Management
Do not coadminister etravirine with dolutegravir unless atazanavir / ritonavir, darunavir / ritonavir, or lopinavir / ritonavir are also part of the regimen. When using this combo and there is known or clinically suspected INSTI resistance, increase dolutegravir dosage to 50 mg BID.
Import ID
536
