Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of rifabutin
Drug 1
Drug 1 effect
Etravirine AUC decreased 37%; Cmax decreased 37%; Cmin decreased 35%
Drug 2
Drug 2 dose
300 mg daily
Drug 2 effect
Rifabutin AUC decreased 17%; Cmin decreased 24%; 25-O-desacetylrifabutin AUC decreased 17%; Cmax decreased 15%; Cmin decreased 22%
Clinical Effects
Decreased rifabutin effects
Management
Administer rifabutin 300 mg once daily with etravirine. If etravirine and a protease inhibitor are used together, do not coadminister with rifabutin.
Import ID
520
