Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of maraviroc
Drug 1
Drug 1 dose
200 mg BID with darunavir / ritonavir 600 / 100 mg BID
Drug 2
Drug 2 dose
150 mg BID
Drug 2 effect
Maraviroc AUC increased 3.10 fold; Cmax increased 1.76 fold; Cmin increased 5.27 fold
Clinical Effects
Increased maraviroc effects
Management
Increase maraviroc to 600 mg BID when combined with etravirine. When etravirine and maraviroc are coadministered with a strong CYP3A4 inhibitor, decrease maraviroc dose to 150 mg BID
Import ID
518
