Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of maraviroc
Drug 1
Drug 1 dose
200 mg BID with darunavir / ritonavir 600 / 100 mg BID
Drug 1 effect
No significant change on etravirine, darunavir or ritonavir pharmacokinetics
Drug 2
Drug 2 dose
300 mg BID
Drug 2 effect
Maraviroc AUC increased 210%; Cmax increased 77%; Cmin increased 430%
Clinical Effects
Increased maraviroc effects
Management
Increase maraviroc to 600 mg BID when combined with etravirine. When etravirine and maraviroc are coadministered with a strong CYP3A4 inhibitor, decrease maraviroc dose to 150 mg BID
Import ID
517
