Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of atorvastatin
Drug 1
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
40 mg daily
Drug 2 effect
Atorvastatin AUC decreased 37% 2-hydroxyatorvastatin AUC increased 27%; Cmax increased 76%
Clinical Effects
Decreased atorvastatin effects
Management
Consider low dose atorvastatin and titrate to effect; monitor for myopathy
Import ID
514
