Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 1 dose
600 mg daily x 35 days
Drug 1 effect
EFV auc decreased 36%, Cmax decreased 21%, Cmin decreased 47%
Drug 2
Drug 2 dose
200 mg daily x 3 days, 200 mg BID x 3 days, 400 mg daily for 15 days
Clinical Effects
Decreased efavirenz and carbamazepine effects
Management
Use alternative agents. If coadministering, monitor carbamazepine levels and adjust as indicated. Monitor antiviral efficacy
Import ID
506
