Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 1 dose
600 mg daily x 14 days
Drug 1 effect
Not studied (may decrease efavirenz levels)
Drug 2
Drug 2 dose
200 mg daily x 3 days, 200 mg BID x 3 days, 400 mg daily for 20 days.
Drug 2 effect
Carbmazepine AUC decreased 27%, Cmin decreased 35%, Cmax decreased 20%
Clinical Effects
Decreased efavirenz and carbamazepine effects
Management
Use alternative agents. If coadministering, monitor carbamazepine levels and adjust as indicated. Monitor antiviral efficacy
Import ID
505
