Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 1 dose
600 mg daily
Drug 1 effect
Efavirenz AUC decreased 22%; Cmin decreased 36%
Drug 2
Drug 2 dose
200 mg daily x 2 weeks, then 400 mg daily
Drug 2 effect
No significant change
Clinical Effects
Decreased efavirenz effects
Management
Monitor and adjust therapy as indicated; may consider increasing efavirenz to 800 mg daily
Import ID
502
