Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 1 dose
400 mg x 7 days
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
500 mg Q12H x 7 days
Drug 2 effect
Clarithromycin AUC decreased 39%; Cmax decreased 26%;14-hydroxy clarithromycin AUC increased 34%; Cmax increased 49%
Clinical Effects
Risk of QT interval prolongation
Management
Dose adjustment not established. Monitor for antbiotic efficacy and / or consider using alternative agents
Import ID
497
