Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: risks likely to outweigh benefits
Drug 1
Drug 1 dose
400 mg daily
Drug 2
Drug 2 dose
300 mg x 1
Drug 2 effect
Proguanil AUC increased 113%; Cmax increased 47%; Cycloguanil AUC decreased 38%; Cmax decreased 31%
Clinical Effects
Potential decreased antimalarial effects
Management
Consider using alternative agents. If coadministering, dose adjustment not established
Import ID
493
