Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: risks likely to outweigh benefits
Drug 1
Drug 1 dose
400 mg BID x 10 and 20 days
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
400 mg BID for 10 and 20 days
Drug 2 effect
Posaconazole AUC decreased 50%; Cmax decreased 45%
Clinical Effects
Decreased posaconazole effects
Management
Consider using alternative agents. If coadministering, dose adjustment has not been established
Import ID
491
