Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: risks likely to outweigh benefits
Drug 1
Drug 1 dose
600 mg x 14 days
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
200 mg Q12H x 28 days
Drug 2 effect
Itraconazole AUC decreased 39%; Cmax decreased 37%; Cmin decreased 44%; Hydroxyitraconazole AUC decreased 37%; Cmax decreased 35%; Cmin decreased 43%
Clinical Effects
Decreased itraconazole effects
Management
Avoid combination and use alternative agents
Import ID
476
