Interaction Color Code
Clinical Bottom Line
Consider using alternative agents
Drug 1
Drug 2
Drug 2 dose
250 mg with 100 mg proguanil x 1
Drug 2 effect
Atovaquone AUC decreased 75%; Cmax decreased 44%. Proguanil AUC decreased 43%
Clinical Effects
Potentially compromised antimalarial activity
Management
If coadministering,dose adjustment not established. Monitor for anti-malarial efficacy.
Import ID
475
