Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of velpatasvir
Drug 1
Drug 1 dose
600 mg (with emtricitabine 200 mg and tenofovir DF 300 mg)
Drug 1 effect
Efavirenz Cmin decreased 19%; AUC decreased 15%; Cmax deceased 10%
Drug 2
Drug 2 dose
400 mg / 100 mg for 14 days
Drug 2 effect
Sofosbuvir Cmax increased 38%. Velpatasvir Cmax decreased 47%; AUC decreased 53%; Cmin decreased 57%
Management
Contraindicated. Use alternative agents.
Import ID
462
