Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of progestin
Drug 1
Drug 1 dose
600 mg daily for 14 days
Drug 2 dose
0.035 mg ethinyl estradiol / 0.25 mg norgestimate x 14 days
Drug 2 effect
Ethinyl estradiol: no significant change; Norgestromin AUC decreased 64%; Cmax decreased 46%; Cmin decreased 82%
Clinical Effects
Decreased effects of ethinyl estradiol and norgestimate
Management
Use alternative contraceptive method
Import ID
457
