Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of progestin
Drug 1
Drug 1 dose
600 mg QHS
Drug 2 dose
0.025 mg ethinyl estradiol / 0.25 mg norgestimate
Drug 2 effect
Ethinyl estradiol: no significant change; Norgestromin AUC decreased 64%; Cmax decreased 46%; Cmin decrased 82%
Clinical Effects
Decreased effects of ethinyl estradiol and norgestimate
Management
Use alternative contraceptive method
Import ID
455
