Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of carbamazepine and efavirenz
Drug 1
Drug 1 dose
600 mg daily on days 1-35
Drug 1 effect
Efavirenz AUC decreased 36%; Cmax decreased 21%; Cmin decreased 47%
Drug 2
Drug 2 dose
200 mg daily on days 1-3, 200 mg BID on days 4-6, 400 mg daily thereafter
Drug 2 effect
Carbamazepine AUC decreased 27%; Cmax decreased 20%; Cmin decreased 35%
Clinical Effects
Decreased efavirenz and carbamazepine levels
Management
Avoid combination and use alternative agents. If coadministering monitor carbamazepine levels and adjust as indicated. Monitor antiviral efficacy
Import ID
443
