Interaction Color Code
Clinical Bottom Line
Do not coadminister: Potential for reduced levels of atazanavir
Drug 1
Drug 1 dose
600 mg daily 2 hours after atazanavir and ritonavir d 7-20
Drug 2
Drug 2 dose
400 mg daily d 1-6, then 300 mg daily days 7_-20 with ritonavir 100 mg daily
Drug 2 effect
Atazanavir auc increased 39%, Cmax increased 48%, Cmin increased 14%.
Clinical Effects
Potential loss of antiviral efficacy
Management
Use alternative agents
Import ID
436
