Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
600 mg daily x 15 days
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
10 mg daily x 5 days
Drug 2 effect
Atorvastatin AUC decreased 43%; Cmax decreased 14%, Cmin decreased 69%. Atorvastatin and metabolites AUC decreased 32%, Cmin decreased 48%, Cmax decreased 15%
Clinical Effects
Decreased lipid effects
Management
Monitor for statin efficacy. May need to increase atorvastatin dose
Import ID
407
