Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
600 mg daily x 15 days
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
stable dose for at least 2 weeks
Drug 2 effect
Buprenorphine AUC decreased 49%; Cmax decreased 45%, Cmin decreased 50%; half-life: decreased 29%
Clinical Effects
Possible decreased buprenorphine effects
Management
Monitor for signs and symptoms of opioid withdrawal; some patients may need an increase in the buprenorphine dose, though study patients did not go into opioid withdrawal
Import ID
404
