Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
600 mg daily
Drug 1 effect
Efavirenz AUC increased 21%; Cmin increased 17%
Drug 2
Drug 2 dose
300 mg BID with ritonavir 100 mg BID
Drug 2 effect
Darunavir Cmin decreased 31%; Cmax decreased 15%; AUC decreased 13%
Clinical Effects
Potential for increased efavirenz effects
Management
Monitor for increased risk of efavirenz related side effects. Consider monitoring drug levels
Import ID
396
