Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
600 mg x 7 days
Drug 1 effect
Efavirenz AUC decreased 26%; Cmax decreased 20%
Drug 2
Drug 2 dose
600 mg x 7 days
Clinical Effects
Decreased efavirenz effects
Management
Monitor for antiviral efficacy. May consider increasing efavirenz to 800 mg daily when used with rifampin
Alternative Agents
Rifabutin
Import ID
393
