Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
600 mg daily x 14 days
Drug 1 effect
Efavirenz AUC decreased 22%; Cmax decreased 24%; Cmin decreased 25%
Drug 2
Drug 2 dose
600 mg daily x 14 days
Drug 2 effect
No significant change
Clinical Effects
Decreased efavirenz effects
Management
Monitor for antiviral efficacy. May consider increasing efavirenz to 800 mg daily for patient's weighing 50 kg or more when used with rifampin
Alternative Agents
Rifabutin
Import ID
392
