Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of voriconazole and increased levels of efavirenz
Drug 1
Drug 1 dose
300 mg daily x 7 days
Drug 1 effect
Efavirenz AUC increased 17%; Cmax no significant change
Drug 2
Drug 2 dose
400 mg Q12H on days 2-7
Drug 2 effect
Voriconazole Cmax increased 23%, AUC decreased 7%
Clinical Effects
Increased efavirenz effects and decreased voriconazole effects
Management
Increase voriconazole to 400 mg Q12H and decrease efavirenz to 300 mg QHS
Import ID
385
