Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of voriconazole and increased levels of efavirenz
Drug 1
Drug 1 dose
400 mg daily x 9 days
Drug 1 effect
Efavrenz AUC increased 44%; Cmax increased 38%
Drug 2
Drug 2 dose
400 mg PO Q12H on day 1, then 200 mg Q12H on days 2-8
Drug 2 effect
Voriconazole AUC decreased 77%; Cmax decreased 61%
Clinical Effects
Increased efavirenz effects and decreased voriconazole effects
Management
Increase voriconazole to 400 mg Q12H and decrease efavirenz to 300 mg QHS
Import ID
382
