Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of voriconazole and increased levels of efavirenz
Drug 1
Drug 1 dose
300 mg QHS x 7 days
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
300 mg Q12H on days 2-7
Drug 2 effect
Voriconazole AUC decreased 55%; Cmax decreased 36% (compared to voriconazole 200 mg BID)
Clinical Effects
Decreased voriconazole effects
Management
Increase voriconazole to 400 mg Q12H and decrease efavirenz to 300 mg QHS
Import ID
379
