Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of simvastatin
Drug 1
Drug 1 dose
600 mg x 15 days
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
40 mg daily x 4 days
Drug 2 effect
Simvastatin AUC decreased 68%; Cmax decreased 72%; Cmin decreased 45%
Clinical Effects
Decreased simvastatin effects
Management
Monitor statin efficacy. May need to increase simvastatin dose
Import ID
378
