Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of simvastatin
Drug 1
Drug 1 dose
600 mg daily on days 4-18
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
40 mg daily on days 0-3 and 15-18
Drug 2 effect
Simvastatin AUC decreased 58%
Clinical Effects
Decreased lipid effects
Management
Monitor statin efficacy. May need to increase simvastatin dose
Import ID
377
