Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of rifabutin
Drug 1
Drug 1 dose
600 mg daily
Drug 1 effect
Not studied
Drug 2
Drug 2 dose
600 mg twice weekly
Drug 2 effect
Rifabutin AUC no significant change; Cmax no significant change (when compared to rifabutin 300 mg twice weekly without efavirenz)
Management
Increase rifabutin to 450-600 mg daily. May use rifabutin 300 mg three times weekly if not coadministered with a protease inhibitor
Import ID
376
